The Costantini Lab | The Costantini Lab

Mission

The Costantini Lab is focused on understanding the role of anti-inflammatory pathways that regulate the resolution of the systemic inflammatory response (SIRS) after severe injury and critical illness. We leverage collaborations with a multi-disciplinary team of scientists to define mechanisms underlying the development of acute lung injury (ALI) that occurs as a consequence of SIRS.

Vision

Approach

We combine in vitro studies with precision in vivo models to improve our understanding of the human inflammatory response to severe injury. Findings from these translationally relevant pre-clinical models are compared with findings from clinical samples obtained from patients during recovery from injury/illness to ensure mechanistic insights and molecular targets are relevant to human inflammation.